Book excerpt: Counseling interventions are a proven and powerful way to help individuals with HIV cope with the enormous changes in their lives wrought by the disease. Proposing an innovative conceptual model for HIV clinical work, this book integrates empirical research on the psychosocial aspects of HIV with extensive case material. It provides a framework for assessing clients' psychosocial concerns and implementing interventions to facilitate adjustment; reviews medical and neurocognitive aspects of HIV disease progression; explores the psychotherapeutic context of HIV clinical work; and addresses risk reduction and prevention.