Book excerpt: Human capital is of utmost importance for the future of our knowledge economies and societies. However, it is unequally distributed in Europe, contributing to marked spatial patterns of economic prosperity within and across countries. In many cases, these patterns have a long history. To understand them better, it requires to go back in time, when mass schooling was starting to become a reality across Europe. Taking a long-run perspective over more than 150 years, this book shows the development and the distribution of human capital in the regions of Europe and its connections with the economy. It provides insights into recent research findings in this area, including theoretical advances and the use of new empirical data.