Book excerpt: This third edition of the classic "how-to" guide incorporates recent changes in policies and procedures of the NIH, with particular emphasis on the role of the Internet in the research proposal process. Completely revised and updated, it reveals the secrets of success used by seasoned investigators, and directs the reader through the maze of NIH bureaucracies. In addition to providing a detailed overview of the entire review process, the book also includes hundreds of tips on how to enhance proposals, excerpts from real proposals, and extensive Internet references. This book is essential to all scientists involved in the grant writing process. Key Features: * Considers the reviewer's perspective * Detailed presentation of the review process * All sections of the R01 proposal are reviewed * Hundreds of tips to enhance proposals * Includes the many recent changes in NIH policies * Includes many excerpts from real proposals * Provides extensive Internet references Benefits: * Increased competitiveness * Better priority scores * Less chance of triage * Increased award rates * Uses the system to advantage * Reveals strategies used by the "old pros"