Book excerpt: This book develops innovative techniques from operational research and management science for the design and implementation of a reconfigurable manufacturing system (RMS), and subsequently analyzes and assesses their performance. A reconfigurable manufacturing system (RMS) is a paradigm that can address many of the challenges posed by the modern market. Accordingly, substantial research is now being conducted on RMS, focusing on various levels of decision-making (strategic, tactical and operational). However, as a relatively new research area, there are still only very few books and articles available on reconfigurable manufacturing system design and management. In addition to filling that gap, this book provides a forum for investigating, exchanging ideas on, and disseminating the latest advances in the broad area of RMS applications in today’s industry. Gathering contributions by experts from academia, industry and policy-making, it represents an essential contribution to the existing literature on manufacturing and logistics in general and industry 4.0 in particular.