Book excerpt: - Expanded information on agents that are seen with increasing frequency in poisoned patients, including lamotrigine and pregabalin - Updated detail on the management of agents including direct oral anticoagulants, digoxin, desvenlafaxine and corrosives - Updated and standardised treatment recommendations for dysrhythmias, particularly resulting from drug-induced conduction abnormalities (QRS and QT prolongation) - Simplified and standardised approaches to management (particularly cardiovascular toxicity from a variety of agents)