Book excerpt: In 'A Different Medicine', Joseph Calabrese presents a case study that challenges many deeply ingrained cultural assumptions and attempts to mediate a centuries-old clash of cultural paradigms. The book explores a controversial Native American ritual and healthcare practice: ceremonial consumption of the psychedelic Peyote cactus in the context of a postcolonial healing movement called the Native American Church. Calabrese argues against the War on Drugs and the Supreme Court decision that jeopardized the right of Native Americans to use this medicine. He urges us to recognize the multiplicity of the normal and the therapeutic.