Book excerpt: Recent developments in diagnostic and therapeutic aspects of cardiac and neonatal issues have advanced the care of the newborn. To achieve excellence in cardiac care, however, close interaction and collaboration of the pediatric cardiologists with neonatologists, pediatricians, general/family practitioners (who care for children), anesthesiologists, cardiac surgeons, pediatric cardiac intensivists, and other subspecialty pediatricians is mandatory. This book provides the reader with up-to-date evidence-based information in three major areas of neonatology and prenatal and neonatal cardiology. First, it provides an overview of advances in the disciplines of neonatology, prenatal and neonatal cardiology, and neonatal cardiac surgery in making early diagnosis and offering treatment options. Secondly, it presents a multidisciplinary approach to managing infants with congenital heart defects. Finally, it provides evidence-based therapeutic approaches to successfully treat the fetus and the newborn with important neonatal issues and congenital cardiac lesions. This first volume specifically explores issues related to perinatal circulation, the fetus, ethics, changes in oxygen saturations at birth, and pulse oximetry screening, diagnosis, and management.