Book excerpt: The Cyber-Physical System (CPS) relates to many other popularized technologies such as Internet of Things (IoT, IIoT), Machine-to-Machine (M2M), Industry 4.0, which describe a vision of connected creations that deeply unite the physical and information domains. As a revolutionary technology, Blockchain (BC) provides a practical solution to enable a secure and decentralized public ledger that a huge plethora of exciting new technology applications in several areas, such as the Internet of Things (IoT), Cyber-Physical Systems, Manufacturing, Supply-Chain, etc. Blockchain technology has infiltrated all areas of our lives, from manufacturing to healthcare and beyond. In this context, this book helps discover the various potential applications that could be fruitful for cyber-physical system applications. It provides a sampling of recent advances and ideas on research progress and the practical usage of blockchain technologies in addressing cyber-physical systems challenges and issues. It provides a sampling of recent advances and views on research progress and the practical usage of blockchain technologies in addressing cyber-physical systems challenges and issues.