Book excerpt: Intelligent Information Systems (IIS) can be defined as the next generation of Information Systems (IS) developed as a result of integration of AI and database (DB) technologies. IIS embody knowledge that allows them to exhibit intelligent behavior, allows them to cooperate with users and other systems in problem solving, discovery, retrieval, and manipulation of data and knowledge. For any IIS to serve its purpose, the information must be available when it is needed. This means that the computing systems used to store data and process the information, and the security controls used to protect it must be functioning correctly. This book covers some of the above topics and it is divided into four sections: Classification, Approximation and Data Security, Knowledge Management, and Application of IIS to medical and music domains.