Book excerpt: Introduction - why breed for drought and low N tolerance?; Conceptual framework - breeding; Conventional approaches to improving the drought and low N tolerance of maize; Conventional approaches challenged; The challenge of breeding for drought and low N tolerance; Maize under drought and low N stress; Conceptual framework - physiology; Water and the maize plant; Nitrogen and the maize plant; Maize under drought and low N stress - consequences for breeding; Stress management; Drought; Low N stress; Statistical designs and layout of experiments; Increasing the number of replicates; Improved statistical designs; Field layout; Border effects from alleys; Secondary traits; Why use secondary traits?; How do we decide on the value of secondary traits in a drought or low N breeding program?; Secondary traits that help to identify drought tolerance; Secondary traits that help to identify low N tolerance: Selection indices - Combining information on secondary traits with grain yield; Combining information from various experiments; Breeding strategies; Choice of germplasm; Breeding schemes; Biotechnology: potential and constraints for improving drought and low N tolerance; The role of the farmer in selection; What is farmer participatory research and why is it important?; What is new about farmer participatory research?; Participatory methodologies.