Book excerpt: Covers the design or redesign of chemicals with the specific intent of making them safe for people and the environment. Explains how commercially useful substances of low toxicity can be designed and developed through careful forethought and strategic molecular modification. Describes how existing industrial chemicals that are toxic can be redesigned to be less toxic but retain their usefulness. Discusses how to merge the disciplines of toxicology and chemistry to design new, less toxic commercial chemicals or redesign existing toxic commercial chemicals to result in less toxic substitutes. Provides researchers, developers, and manufacturers of industrial chemicals with a reference source for designing safer chemicals.