Book excerpt: Examines America's experience with a wide range of quarantine practices over the past 400 years and the political, economic, immigration, and public health considerations that have prompted success or failure within the evolving role of public health. The novel strain of coronavirus that emerged in late 2019 and became a worldwide pandemic in 2020 is only one of more than 87 new or emerging pathogens discovered since 1980 that have posed a risk to public health. While many may consider quarantine an antiquated practice, it is often one of the only defenses against new and dangerous communicable diseases. Tracing the United States' quarantine practices through the colonial, postcolonial, and modern eras, Germs at Bay provides an eye-opening look at how quarantine has worked despite routine dismissal of its value. This book is for anyone seeking to understand the challenges of controlling the spread of COVID-19 and helps readers internalize the lessons learned from the pandemic. Few titles provide this level of primary source data on the United States' long reliance on quarantine practices and the political, social, and economic factors that have influenced them.