Book excerpt: Constraining the magma evolution and dynamics that lead to the eruption of large volume continental arc systems is fundamental to our understanding of continental crust formation. An investigation into the magmagenesis that results in the formation of the Central Volcanic Zone (CVZ) in the Andes of South America, situated atop overthickened continental crust (80 km thick), provides insights into large volume silicic magma reservoirs and how they evolve prior to their potentially catastrophic explosive eruption on the Earth's surface. A focused case study of the Cerro Guacha Caldera Complex (CGCC), a nested volcanic system in the Altiplano-Puna Volcanic Complex of SW Bolivia, puts constraints on the progressive stages of development of the magmatic underpinnings of the caldera complex. Whole rock data, in conjunction with matrix glass, mineral compositions and melt inclusions, are used to infer processes that gave rise to the formation of the Guacha II Caldera, the younger of two main collapse features, formed from the supereruption of the Tara Ignimbrite (800 km3 DRE) at 3.49 ± 0.01 Ma. The eruptive history of the Guacha II Caldera from pre-caldera to post-caldera is fully represented, allowing magma dynamics associated with a complete caldera cycle, from pre-climactic (catastrophic caldera-forming) magma accumulation through to post-climactic effusions that are part of the resurgent history of the caldera, to be examined. Analysis of the high-K, calcalkaline suite of andesite to high Si-rhyolite Tara pyroclastic deposits provides insights into the storage conditions and magma dynamics leading up to a supervolcanic eruption. The Tara eruptive products define a liquid line of descent from the basal andesite lava (62 wt % SiO2) to the high-silica rhyolite post-collapse Chajnantor Dome lava (78 wt.% SiO2), with major and trace element trends consistent with fractionation of quartz, plagioclase, orthopyroxene, hornblende, sanidine, biotite, and Fe-Ti oxides. Isotope ratios span a significant range in 87Sr/86Sr (0.709 to 0.713) and a relatively narrow range in 143Nd/144Nd (0.512179 to 0.512297) and [delta]18O[subscript (qtz)] (+8.68 to +8.43[per mil]). These data require AFC processes to explain both the isotope and trace element compositions in the Tara magmas. Geothermobarometry reveals pre-eruptive temperatures (~800 - 950 °C), pressures (~200 MPa), and H2O contents (~5 wt%) that suggest storage of a large-volume rhyodacite magma reservoir between 5 and 9 km depth in the upper crust. Analyses of quartz-hosted melt inclusions from pumices in the climactic plinian and ignimbrite phase of eruption reveal that pre-eruptive H2O contents in the plinian pumice overlap with those in the ignimbrite pumice (2.2 to 6.0 and 2.1 to 5.4 wt.% H2O, respectively). The ignimbrite magma, however, contains higher CO2 (630 versus