Book excerpt: Meaning-Centered-Psychotherapy in the Cancer Setting provides a theoretical context for Meaning-Centered Psychotherapy (MCP), a non-pharmalogic intervention which has been shown to enhance meaning and spiritual well-being, increase hope, improve quality of life, and significantly decrease depression, anxiety, desire for hastened death, and symptom burden distress in the cancer setting. Based on the work of Viktor Frankl and his concept of logotherapy, MCP is an innovative intervention for clinicians practicing in fields of Psycho-oncology, Palliative Care, bereavement, and cancer survivorship. This volume supplements two treatment manuals, Meaning-Centered Group Psychotherapy (MCGP) for Patients with Advanced Cancer and Individual Meaning -Centered Psychotherapy (IMCP) for Patients with Advanced Cancer by Dr. Breitbart, which offer a step-wise outline to conducting a specific set of therapy sessions. In addition to providing a theoretical background on the MCP techniques provided in the treatment manuals, this volume contains chapters on adapting MCP for different cancer-related populations and for different purposes and clinical problems including: interventions for cancer survivors, caregivers of cancer patients, adolescents and young adults with cancer, as a bereavement intervention, and cultural and linguistic applications in languages such as Mandarin, Spanish, and Hebrew.