Book excerpt: Pathophysiology – what is the cause? Clinical significance – what does it mean? Diagnosis and treatment – what is the predictive value? These are questions that all clinicians should continue to ask themselves from the very beginning of medical training and throughout a lifetime of practice. Organised by body system, Mechanisms of Clinical Signs 3e describes the underlying pathway, differential diagnoses and value of the clinical signs seen during physical examination. - Alphabetical listing of clinical signs - Index by sign and conditions for easy reference - Additional flow diagrams - Clinical Pearls highlighting important clinical signs - Summary of the evidence - Access to chapter-based MCQs Access StudentConsult for: - Clinical videos and audio of key signs - Case-based MCQs - An Enhanced eBook. The enhanced eBook allows the end user to access all of the text, figures, and references from the book on a variety of devices.