Book excerpt: This book constitutes the refereed proceedings of the Third International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2000, held in Pittsburgh, PA, USA in October 2000.The 136 papers presented were carefully reviewed and selected from a total of 194 submissions. The book offers topical sections on neuroimaging and neuroscience, segmentation, oncology, medical image analysis and visualization, registration, surgical planning and simulation, endoscopy and laparoscopy, cardiac image analysis, vascular image analysis, visualization, surgical navigation, medical robotics, plastic and craniofacial surgery, and orthopaedics.