Book excerpt: Neutrosophic Logic is a tool based on non-standard analysis to represent mathematical model of uncertainty, vagueness, ambiguity, incompleteness, and inconsistency. In Neutrosophic set, indeterminacy is quantified explicitly whereas the truth membership, indeterminacy membership, and falsity membership are independent. This plays a vital role in many situations whenwehandle inconsistent and incomplete information. In modeling problems, differential equations have major applications in the field of science and engineering and the study of differential equationwith uncertainty is one of emerging field of research. In this paper, the differential equations in neutrosophic environment are explored, also the solution of second-order linear differential equation with trapezoidal neutrosophic numbers as boundary conditions is discussed. Furthermore, the numerical example is given to demonstrate the solution with different values of (α, β, γ )-cut of trapezoidal neutrosophic number.