Book excerpt: Generalized Anxiety Disorder may be seen as a gateway condition from normalcy to pathology with blurred boundaries towards several concurrent disorders. This anxiety illness is responsible for psychological suffering and personal dysfunction in a considerable proportion of individuals in the general population. Since its original definition in the DSM-III (1980), the clinical and scientific interest in Generalized Anxiety Disorder has grown, becoming a challenge for researchers and practitioners nowadays. This book provides a modern viewpoint with intriguing insights on relevant topics, including historical frameworks, epidemiology, basic neurobiological sciences, clinical presentation and complexity, and major treatment options. The list of contributors include professors, researchers, PhD students, clinical psychiatrists and psychologists; they belong to different universities and training institutions and all of them possess a distinguished expertise in the specific fields of interest. Psychiatrists, physicians, psychologists, residents and undergraduate students may take advantage of this book, from both clinical and research-oriented perspectives.