Book excerpt: 'Pediatrics and Perinatology: The Scientific Basis' addresses the molecular biology, biochemistry and physiological mechanisms by which the fetus, newborn infant, and child develop normally. Specific disease states that involve abnormalities are examined in detail. All major organ systems are covered (e.g. immune system, cardiovascular system), and in addition, biological areas specific or particularly important to these developmental periods are covered separately (e.g. growth, temperature regulation). Previously entitled 'Perinatal and Pediatric Pathophysiology', the second edition has been extensively revised and updated, to ensure it provides essential information for the trainee paediatrition or neonatologist. The chapters on membrane, cellular and molecular biology and on immunology have been totally rewritten. New chapters have been added on genetics, clinical genetics and on bone, connective tissue and skin development. The chapter on neurophysiology is greatly extended with reference to both basic physiology and developmental aspects.