Book excerpt: This book presents a structured approach to develop mathematical optimization formulations for several variants of facility layout. The range of layout problems covered includes row layouts, floor layouts, multi-floor layouts, and dynamic layouts. The optimization techniques used to formulate the problems are primarily mixed-integer linear programming, second-order conic programming, and semidefinite programming. The book also covers important practical considerations for solving the formulations. The breadth of approaches presented help the reader to learn how to formulate a variety of problems using mathematical optimization techniques. The book also illustrates the use of layout formulations in selected engineering applications, including manufacturing, building design, automotive, and hospital layout.