Book excerpt: What needs to happen if we are going to feed almost 10 billion people by the year 2050 in a sustainable way? Written for first- and second-year university students, this interdisciplinary textbook addresses this challenging question, presenting biological, economic, and sociocultural issues at an introductory level. Presenting and integrating information from many disciplines, this book invites readers to consider the complexity of feeding humanity and increasing food production sustainably. Topics covered include: the development, physiology, and nutrition of plants human nutrition and food safety photosynthesis and energy transformations genetics, molecular biology, and genomics, including the techniques of genetic transformation (gene silencing, gene editing with CRISPR) used in modern crop breeding crop domestication and plant breeding soil ecosystems The applications of modern biotechnology to agriculture extend far beyond GMOs, and include crop improvements that rely on knowledge of the plant’s genomes and its analysis by bioinformatics. Challenging and controversial topics such as the safety of pesticides and GMOs, the increasing demand foranimal products and the stresses this puts on agricultural output, organic farming and foods, and patenting new crop varieties are dealt with in a balanced way, inviting teachers and students to consider all the implications of these serious questions.