Book excerpt: This quick-reference pocket book is written for primary care practitioners who face diagnostic problems in brief office visits. It offers evidence-based guidelines on which key questions to ask and what data to obtain in order to provide sound diagnoses of common adult problems. More than 140 chapters in eighteen sections cover mental health problems, symptoms and signs in each organ system, laboratory abnormalities, and radiologic abnormalities. This edition has been thoroughly updated by new editors. New chapters cover corneal foreign body, hematuria, brain natriuretic peptide in congestive heart failure, and D-dimer. The format includes more quick-scanning bullets and tables.