Book excerpt: By 2020 depression is expected to be a leading cause of disability worldwide, second only to heart disease. Despite the dozens of antidepressants on the market, millions of people who seek treatment for depression fail to find ongoing relief from their symptoms. Others must go through months of medication trials before finding the prescription(s) that works best for them. In The Breakthrough Depression Solution: A Personalized 9-Step Method for Beating the Physical Causes of Your Depression, board-certified psychiatrist James Greenblatt, MD, lays out a proven approach to identifying and healing the physical contributors to your depression, which may include nutrition, genetics, hormones, and stress. Finding the right treatment is easier than people think and may be as simple as taking a vitamin or mineral tablet. The author discusses the latest technology and the many tests available to ensure that medications and other treatments are targeted to each individual's unique biochemistry for the best outcome possible. Book jacket.