Book excerpt: In collaboration with its partners, the Food and Agriculture Organization of the United Nations (FAO) leads the integration, in a structured, holistic and coherent manner, of actions for the conservation, sustainable use, management and restoration of biological diversity across agricultural sectors at national, regional and international levels. Against this background, FAO has developed a series of instruments and tools related to biodiversity for food and agriculture (BFA) that can contribute to the implementation of the FAO Global Strategy on Mainstreaming Biodiversity across Agricultural Sectors, Post-2020 Global Biodiversity Framework and the UN Decade on Ecosystem Restoration 2021–2030, and in alignment with the mitigation and adaptation agenda of the UNFCCC. In line with its programming and operationalization mandate to address regional priorities, the FAO Regional Office for Europe and Central Asia (REU) via the Regional Initiative n°3 on Managing natural resources sustainably and preserving biodiversity in a changing climate, developed the Regional Action plan for biodiversity mainstreaming across agricultural sectors in 17 programming countries of Europe and Central Asia. During 2022–2023, it aims at addressing the priority regional challenges.