Book excerpt: In 2001 Graves' Disease: A Practical Guide described the causes, diagnosis, treatment and disease course of Graves' disease and other hyperthyroid disorders, such as toxic multinodular goiter, thyroiditis, resistance to thyroid hormone, and hyperthyroidism caused by medications and genetic mutations. The present work continues the above but focuses on subsequent advances in disease pathology, including discoveries regarding the genetic, immune system, and environmental factors that lead to hyperthyroid disorders; new guidelines for conventional treatment; and alternative and complementary medical therapies. Additional sections describe special circumstances such as hyperthyroidism in pregnancy and in children and transient hyperthyroidism in the newborn.