Book excerpt: Nurses need to be aware of the latest information, technologies, and research available to provide safe, patient-centered, evidence-based care. Applied Clinical Informatics for Nurses continues its' student-centered approach to nursing informatics in a modern new edition full of illustrations, tables, figures, and boxes that enhance the readers’ experience and assists in comprehension. In the updated Third Edition, the authors emphasize the importance of understanding principles and applications of informatics and apply a context-based teaching approach to enhance clinical decision-making, promote ethical conduct, and improve problem-solving skills. The Third Edition features extensive updates on telehealth, mobile health, and clinical decision support. It also includes expanded information related to software used for data mining and additional case studies to help illustrate creative informatics projects developed by nurses.