Book excerpt: The exploration of the subnuclear world is done through increasingly complex experiments covering a wide range of energy and performed in a large variety of environments ranging from particle accelerators, underground detectors to satellites and the space laboratory. Among recent advances one has to indicate, for instance, first results obtained from space and LHC experiments and progress done in preparation of the latter experiments upgrades, including plans for the LHC machine upgrade. The achievement of these research programs calls for novel techniques, new materials and instrumentation to be used in detectors, often of large scale. Therefore, fundamental physics is at the forefront of technological advance and also leads to many applications. Among these, medical applications have a particular importance due to health and social benefits they bring to the public.