Book excerpt: Experts are constantly trying to understand the complex relationships between humans and evolving technologies. Cognitive ergonomics, the science behind human-machine interactions, ensures optimal performance and decision-making. Understanding and managing these interactions, especially in medicine and computer tasks, requires an interdisciplinary approach. Bioethics of Cognitive Ergonomics and Digital Transition addresses these challenges head-on, offering a comprehensive exploration of cognitive ergonomics and its implications for technology, society, and more. One of the critical issues addressed in this book is the ethical design and implementation of human-machine interactions, particularly in biomedical research and treatment contexts. As technologies like artificial intelligence (AI) and biotechnology continue to advance, the need for ethical frameworks becomes increasingly critical. This book examines the bioethical perspectives of these interactions, providing readers with insights into how to navigate these complex issues responsibly.