Book excerpt: This comprehensive text presents cutting-edge advances in the theory and methodology of modeling and simulation (M&S) and reveals how this work has been influenced by the fundamental contributions of Prof. Tuncer Ören to this field. Exploring the synergies among the domains of M&S and systems engineering (SE), the book describes how M&S and SE can help to address the complex problems identified as “Grand Challenges” more effectively under a model-driven and simulation-directed systems engineering framework. Features: examines frameworks for the development of advanced simulation methodologies; presents a focus on advanced modeling methodologies; reviews the reliability and quality assurance of models; discusses the specification and simulation of human and social behavior, including models of personality, emotions, conflict management, perception and anticipation; provides a survey of the body of knowledge in M&S; highlights the foundations established by the pioneering work of Prof. Tuncer Ören.