Book excerpt: The current healthcare framework, often characterized by standardized treatments and one-size-fits-all approaches, falls short in addressing the unique genetic compositions, lifestyles, and environmental factors that influence individual patient outcomes. This gap necessitates a radical reevaluation of healthcare practices, from reshaping infrastructure to redefining the roles of patients and doctors. The challenges are formidable, requiring critical reflection and bold initiatives to overcome obstacles and pave the way for a future where patient-centered care seamlessly integrates with population health management, leveraging data, technology, ethics, and collaboration for a global healthcare revolution. Convergence of Population Health Management, Pharmacogenomics, and Patient-Centered Care is a book that unveils a comprehensive exploration of solutions and pathways towards this transformative vision. This comprehensive guide is tailored for academic scholars, healthcare professionals, and students navigating the landscape of personalized medicine, population health management, and the digitalization of healthcare. Authored by leading experts, the book aims to serve as a compendium of terms, definitions, and in-depth explanations of key concepts. Its objectives include supporting students in understanding healthcare domains, aiding healthcare professionals in meeting patient needs, assisting patients in deriving more benefits from their healthcare, and guiding e-health systems' designers and managers in grounding practices on the science of individuality.