Book excerpt: This Fourth Edition of the CRC Handbook of Laboratory Safety expands and updates the discussions found in the previous editions. The latest technologies and issues are incorporated to keep managers and laboratory personnel up-to-date on programs to meet the needs of new regulations.Every attempt has been made to ensure that the current edition is as up-to-date as possible by continually reviewing current regulatory standards. Every article has been revised to reflect the newest changes. Topics may be similar but the content may have changed significantly. The wealth of information easily accessible in this new edition continues to make the CRC Handbook of Laboratory Safety an essential reference tool.