Book excerpt: This book pragmatically explores the myths, concepts, policies, key conditions and tools for enhancing creative knowledge cities. The authors provide a critical reflection on the reality of city concepts including university-city alignment for campus planning, labour market conditions, social capital and proximity, triple helix based transformation, and learning by city governments. Original examples from both the EU and US are complemented by detailed case studies of cities including Rotterdam, Vienna and Munich. The book also examines the reality of knowledge cities in emerging economies such as Brazil and China, with a focus on institutional transferability. Key conditions addressed include soft infrastructure, knowledge spillovers among firms and the connectivity of cities via transport networks to allow the creation of new hubs of knowledge-based services.