Book excerpt: This book represents the most current development on the expanding and changing field of telemedicine and e-health, especially in the developing countries. Many things have changed since the publication of the first book in 2004 (Establishing Telemedicine in Developing Countries: From Inception to Implementation). Telemedicine has become more popular, and still continues to grow. While there are many good books and materials on telemedicine, this publication can be seen at the work of reference for all of those who want to practice telemedicine and e-health, particularly in developing countries. This publication deals with ways to establish telemedicine and e-health system, not only in the developing countries, but also in the developed world. Hopefully, this book will be a guide that reflects the status of telemedicine at the given time. It is dedicated to all future generations of telemedicine and e-health students which include healthcare practitioners, administrators, policy makers, technical professionals and others.