Book excerpt: Closed Loop Supply Chains and its management have become mandatory for firms to stay competitive and profitable. This book provides insights for designing supply chain networks by understanding and incorporating key return parameters into the network design, which will affect profitability. The book discusses how customer categories and their acceptance behavior is incorporated into the network design. It will also show how to analyze the interaction of parameters on supply chain network design and profitability, offers modeling framework for incorporating uncertainties in the return product parameters, and how to design a robust network. Invaluable for managers in designing a sustainable, robust, and profitable supply chain network and ideal for managers, practitioners, and researchers in the area of supply chain network design and optimization.