Book excerpt: Precision medicine is a topical subject that attracts tremendous attention from scientific and medical communities, being set to transform health care in the future. This book will be among the first to cover the detection methods for precision medicine. The first section provides an overview of the biomarkers used for precision medicine, such as proteins, nucleic acids, and metabolites. The coverage then turns to sequencing techniques and their applications, and other bioanalytical techniques, including mass spectrometry for proteome and phosphoproteome analysis, immunological methods and droplet technologies. The final sections include biosensors applied to precision medicine and clinical applications. This book provides a reference for researchers and students interested and working in the development of bioanalytical techniques for clinical applications. It provides a useful introduction for physicians and medical laboratory technologists to the recent advances in detection methods for precision medicine.