Book excerpt: Provides an introduction to the fundamental concepts of fuzziness together with a compilation of recent advances in the application to medicine. The tutorials in the first part of the book range from basic concepts through theoretical frameworks to rule simplification through data clustering methodologies and the design of multivariate rule bases through self-learning by mapping fuzzy systems onto neural network structures. The case studies which follow are representative of the wide range of applications currently pursued in relation to medicine. The majority of applications presented in this book are about bridging the gap between low-level sensor measurements and intermediate or high-level data representations. The book offers a comprehensive perspective from leading authorities world-wide and provides a tantalising glimpse into the role of sophisticated knowledge engineering methods in shaping the landscape of medical technology in the future.