Book excerpt: This book constitutes the refereed proceedings of the 10th International Conference on Global Security, Safety and Sustainability, ICGS3 2015, held in London, UK, in September 2015. The 31 revised full papers presented were carefully reviewed and selected from 57 submissions. The papers focus on the challenges of complexity, rapid pace of change and risk/opportunity issues associated with the 21st century living style, systems and infrastructures.