Book excerpt: Over the decades, the fields of health information systems and informatics have seen rapid growth. Such integrative efforts within the two disciplines have resulted in emerging innovations within the realm of medicine and healthcare. The Handbook of Research on Emerging Perspectives on Healthcare Information Systems and Informatics provides emerging research on the innovative practices of information systems and informatic software in providing efficient, safe, and impactful healthcare systems. While highlighting topics such as conceptual modeling, surveillance data, and decision support systems, this handbook explores the applications and advancements in technological adoption and application of information technology in health institutions. This publication is a vital resource for hospital administrators, healthcare professionals, researchers, and practitioners seeking current research on health information systems in the digital era.