Book excerpt: Health Promotion and Disease Prevention for Advanced Practice: Integrating Evidence-Based Lifestyle Concepts is a unique new resource that is not afraid to address lifestyle concepts that can change the trajectory of healthcare in the United States and globally. It provides practical, evidence-based approaches to reduce the pandemic of preventable lifestyle-related chronic diseases such as heart disease, hypertension, some strokes, type 2 diabetes, obesity, and multiple types of cancer. It provides nurse practitioners and physician assistants with the lifestyle management tools needed to contribute to a higher level of care to promote health and prevent disease. The authors take a deep dive into the literature regarding lifestyle concepts and practical management of lifestyle-related chronic diseases. They discuss the root causes of diseases and approaches for patient-centered care, strategies for health promotion reimbursement, and trending telehealth delivery of health care.