Book excerpt: In this issue of Surgical Oncology Clinics, guest editors Drs. Adam Yopp and Maria B. Majella Doyle bring their considerable expertise to the topic of Hepatocellular Carcinoma. Top experts in the field explore promising recent advances in the treatment of all stages of hepatocellular carcinoma (HCC), neoadjuvant or downstaging therapy, the role of LI-RADS in hepatocellular carcinoma, surveillance of hepatocellular carcinoma, liver transplantation, and more. - Contains 13 relevant, practice-oriented topics, including the changing epidemiology of HCC within the US and worldwide; HCC surveillance: evidence-based tailored approach; surgical resection outside early stage HCC; minimally invasive techniques for HCC resection; overview of current HCC staging systems: is there an optimal system?; and more. - Provides in-depth clinical reviews on hepatocellular carcinoma, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.