Book excerpt: This book focuses on the role of hydrogen sulfide in the protection of plants against abiotic stresses and abiotic stress-induced complications by the way of converging advanced key methods of proteomics, genomics, and metabolomics. It provides an update on the biosynthesis, signaling, and mechanism of action of hydrogen sulfide in combating abiotic stresses in plants. Also, special emphasis is given to the interaction of hydrogen sulfide with other signaling molecules (such as nitric oxide, carbon monoxide, hydrogen peroxide etc.), phytohormones, mineral nutrients, ions, and ion channels in plants. This work, uniquely, covers key aspects of hydrogen sulfide signaling in relation to abiotic stresses in plants, including programmed cell death, stomatal movement, and fruit ripening.