Book excerpt: The human brain, still in 2024 the great beyond of biological engineering, operates with a complexity that has long inspired technological advancements. In the ethos of Web4, comprising the Internet of Things (IoT), Artificial Intelligence (AI), Quantum Computing, and self-healing hardware, we observe remarkable parallels to the brain’s functionality. This section explores these similarities, positing that insights from neuroscience can inform and enhance the development of Web4 technologies. Through a detailed comparison, we illustrate how the brain’s mechanisms of decision-making, self-repair, and resilience can be mirrored in these cutting-edge emerging technologies.