Book excerpt: This issue of Critical Care Clinics, edited by Dr. Kianoush Kashani in collaboration with Consulting Editor Dr. John Kellum, is focused on Intensive Care Unit Telemedicine. Topics in this issue include: ICU telemedicine program administration: from start to full implementation; ICU telemedicine multidisciplinary care teams; ICU telemedicine technology; Impact of ICU telemedicine on outcomes; Quality assurance of ICU telemedicine; ICU telemedicine cost-effectiveness and financial analyses; ICU telemedicine care models; ICU telemedicine in the era of big data, artificial intelligence, and computer clinical decision support systems; ICU Telemedicine: Innovations and Limitations; ICU telemedicine: provider-patient satisfaction; and ICU telemedicine services beyond medical management: Tele-pharmacy, tele-procedure, tele-dialysis, tele-stroke: evidence, benefits, risks, and legal ramifications.