Book excerpt: In this issue of Orthopedic Clinics, guest editors from the esteemed Campbell Clinic bring their considerable expertise to the topic of Intraoperative Challenges. Eleven top experts discuss a wide variety of potential surgical challenges that require the surgeon to make important judgment calls and decide the proper course of action. Areas covered include knee and hip reconstruction, hand and wrist, foot and ankle, shoulder and elbow, spine, trauma, and pediatrics. - Contains 14 relevant, practice-oriented topics including challenges with intraoperative imaging for pelvic and acetabular surgery; neuromonitoring changes in spinal deformity surgery; intraoperative challenges in hand surgery; managing intraoperative fractures during total ankle replacement; intraoperative vertebral artery injury: evaluation, management and prevention; and more. - Provides in-depth clinical reviews on intraoperative challenges, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.