Book excerpt: "Introduction to Skin Biothermomechanics and Thermal Pain" introduces the study of coupled bio-thermo-mechanical and neural behavior of skin tissue in response to thermal and mechanical loads. The research in this book focuses on the theoretical modeling and experimental investigation of heated skin tissue in order to provide a predictive framework for thermal therapies of diseased tissue in clinics. Furthermore, by developing solution tools, it focuses on changes in treatment parameters leading to more effective therapies. The book is intended for researchers and scientists in Bioengineering, Heat Transfer, Mechanics, Biology and Neurophysiology, as well as clinicians. Dr. Feng Xu is a research fellow at Harvard Medical School, Boston, MA, USA. Dr. Tianjian Lu is a professor at the School of Aerospace, Xi'an Jiaotong University, Xi'an, China. Dr. Xu and Dr. Lu are also affiliated with Biomedical Engineering and Biomechanics Center at Xi'an Jiaotong University, Xi'an, China.