Book excerpt: This book constitutes the refereed proceedings of the 4th IFIP TC 5, TC 12, WG 8.4, WG 8.9, WG 12.9 International Cross-Domain Conference, CD-MAKE 2020, held in Dublin, Ireland, in August 2020. The 30 revised full papers presented were carefully reviewed and selected from 140 submissions. The cross-domain integration and appraisal of different fields provides an atmosphere to foster different perspectives and opinions; it will offer a platform for novel ideas and a fresh look on the methodologies to put these ideas into business for the benefit of humanity. Due to the Corona pandemic CD-MAKE 2020 was held as a virtual event.