Book excerpt: Multi-valued neutrosophic sets (MVNSs) consider the truth-membership, indeterminacy-membership, and falsity-membership simultaneously, which can more accurately express the preference information of decision-makers. In this paper, the normalized multi-valued neutrosophic distance measure is developed firstly and the corresponding properties are investigated as well. Secondly, the normalized multi-valued neutrosophic distance difference is defined and the corresponding partial ordering relation is discussed. Thirdly, based on the developed distances and comparison method, an extended multi-valued neutrosophic QUALItative FLEXible multiple criteria (QUALIFLEX) method is proposed to handle MCDM problems where the weights of criteria are completely unknown. Finally, an example for selection of medical diagnostic plan is provided to demonstrate the proposed method, together with sensitivity analysis and comparison analysis.