Book excerpt: This book asserts the emergence of the fourth era of entrepreneurship, based on a brain-driven approach to the study, instruction, and practice of entrepreneurship. This paradigm shift stems from the need to incorporate appropriate neurotechnologies into the exploration and enhancement of entrepreneurial phenomena in order to best address the field's methodological challenges. The author explains why a paradigm shift is necessary in the field of entrepreneurship and provides the foundational guidelines for those interested in implementing it. Furthermore, a model of entrepreneurial enhancement is conceptualized and signalled as the ultimate goal of this new era. Scholars, practitioners, policymakers, and students interested in advancing entrepreneurship's contribution to academia, business, and society at large will benefit from this new era's multidisciplinary perspective and unique strengths.