Book excerpt: Sleep-disordered breathing, ranging from habitual snoring to severe obstructive sleep apnea, is highly prevalent and represents a growing global healthcare burden. Besides disrupting sleep, sleep-disordered breathing leads to detrimental outcomes such as excessive daytime sleepiness, neurocognitive impairment, and increased cardiometabolic morbidities. The gold standard diagnostic procedures (e.g., in-lab polysomnography) are cumbersome and standard parameters derived from sleep studies often yield poor long-term prognostic value. Hence, there is a need for innovative diagnostic technologies and novel sleep metrics to enable simple diagnosis and tailored disease management.