Book excerpt: At the cross-roads of biology, microfluidics and photonics the field of optofluidics allows for quick and compact solutions for medical and biochemical sensing and manipulation. This book is concerned with the ingredients for a polymer-based platform which is able to culture and pattern life cells for a sufficient period of time, enables the integration of photonic devices, and provides means to integrate electronic readout. Thus – in its cross-discipline approach – it touches on aspects of photonics, nanofabrication, and biological methods alike.